Tesamorelin
Tesamorelin is a GHRH analogue. In the US, EGRIFTA WR is approved for excess abdominal fat in adults with HIV-associated lipodystrophy.
Approvals
Peptipedia explains research and prescribing information. It does not replace medical advice and is not an invitation to use a substance.
Research areas
Evidence matrix
- Molecular identity
- Confirmed
Tesamorelin is a defined GHRH analogue. The US approval applies to EGRIFTA WR, not to arbitrary compounded products.
- Human research
- Strong
- Replication
- Single research group
- Clinical endpoints
- Symptom- or function-related
- Safety
- Characterized by prescribing information or extensive studies
- Approval
- US · Approved
The dimensions are presented separately and are not combined into an overall score.
What the source shows
Approval covers a specific indication, not general weight loss.
- EGRIFTA WR: US prescribing informationPrescribing information2025
U.S. National Library of Medicine (DailyMed)
Accessed:
Research gaps
- ·Long-term cardiovascular safety is unresolved.
- ·Short profile: not a complete benefit–risk assessment. Unlisted contraindications and interactions are not adequately established in this profile; missing information does not establish safety.
Mechanism
It stimulates endogenous growth hormone release.
- EGRIFTA WR: US prescribing informationPrescribing information2025
U.S. National Library of Medicine (DailyMed)
Accessed:
Study protocols
No sufficiently supported, exactly citable study protocols are available.
Calculator
Arithmetic based only on your entries. Not a dose or use recommendation.
Reported adverse effects
- ·Risks include fluid retention, elevated IGF-1 and impaired glucose regulation.
Contraindications and warnings
- ·Contraindications include active malignancy and pregnancy; consult the full prescribing information.
Interactions
No reviewed information on this point has been recorded here yet. This does not mean there are no risks or contraindications.
Research gaps
- ·Long-term cardiovascular safety is unresolved.
- ·Short profile: not a complete benefit–risk assessment. Unlisted contraindications and interactions are not adequately established in this profile; missing information does not establish safety.
- EGRIFTA WR: US prescribing informationPrescribing information2025
U.S. National Library of Medicine (DailyMed)
Accessed:
- EMA: withdrawal of the Egrifta marketing-authorisation applicationRegulatory source2012
European Medicines Agency
Accessed:
Sources
Sources checked: · Version 2
- EGRIFTA WR: US prescribing informationPrescribing information2025
U.S. National Library of Medicine (DailyMed)
Accessed:
- EMA: withdrawal of the Egrifta marketing-authorisation applicationRegulatory source2012
European Medicines Agency
Accessed: