IGF-1 LR3
Long R3 insulin-like growth factor I
IGF-1 LR3 is a modified IGF-I analogue used experimentally. The captured source is a cell study, not treatment in people.
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Research areas
Evidence matrix
- Molecular identity
- Confirmed
LR3-IGF-I is the IGF-I analogue named in the cited cell study. It is not interchangeable with native IGF-1, mecasermin or unspecified commercial products.
- Human research
- None
- Replication
- Single research group
- Clinical endpoints
- No clinical endpoints
- Safety
- Not adequately studied
- Approval
- No documented approval
The dimensions are presented separately and are not combined into an overall score.
What the source shows
Cultured human skin fibroblasts were studied outside the body; the source provides no clinical efficacy or safety assessment.
- The role of IGFBP-3 in the regulation of IGFBP-4 proteolysisLaboratory study1996
Donnelly MJ; Holly JM
Accessed:
Research gaps
- ·Evidence for native IGF-1 or approved mecasermin must not be transferred to LR3. Clinical pharmacokinetics and benefit are absent.
- ·Short profile: not a complete benefit–risk assessment. Unlisted contraindications and interactions are not adequately established in this profile; missing information does not establish safety.
Mechanism
The study compared LR3 with IGF-I and other analogues and describes different binding-protein interactions and cellular effects.
- The role of IGFBP-3 in the regulation of IGFBP-4 proteolysisLaboratory study1996
Donnelly MJ; Holly JM
Accessed:
Study protocols
No sufficiently supported, exactly citable study protocols are available.
Calculator
Arithmetic based only on your entries. Not a dose or use recommendation.
Reported adverse effects
- ·Evidence is insufficient; absence of data is not evidence of safety. Clinical risks, including metabolic and proliferative effects, have not been adequately studied for LR3.
Contraindications and warnings
No reviewed information on this point has been recorded here yet. This does not mean there are no risks or contraindications.
Interactions
No reviewed information on this point has been recorded here yet. This does not mean there are no risks or contraindications.
Research gaps
- ·Evidence for native IGF-1 or approved mecasermin must not be transferred to LR3. Clinical pharmacokinetics and benefit are absent.
- ·Short profile: not a complete benefit–risk assessment. Unlisted contraindications and interactions are not adequately established in this profile; missing information does not establish safety.
- The role of IGFBP-3 in the regulation of IGFBP-4 proteolysisLaboratory study1996
Donnelly MJ; Holly JM
Accessed:
Sources
Sources checked: · Version 3
- The role of IGFBP-3 in the regulation of IGFBP-4 proteolysisLaboratory study1996
Donnelly MJ; Holly JM
Accessed: